| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Microfluidic fabrication of poly(N-vinyl caprolactam)-based microcarriers for modulated thermo-responsive drug release |
| 초록 |
For the realization of therapeutic efficacy, controlled drug delivery system is important. Here, we introduce Poly(N-vinyl caprolactam) (PVCL) microparticles for temperature-responsive drug delivery. PVCL-based microparticles were synthesized via Stop Flow Lithography (SFL) process. Polymer network in microparticles are contracted above certain temperature known as lower critical solution temperature (LCST) behavior. After adjusting the LCST to body temperature by adding hydrophilic component, we conducted the drug release test using doxorubicin as a model drug and revealed that the releasing rates were significantly higher at above LCST. By taking advantage of SFL, we fabricated multicompartmental PVCL microparticles and showed that more than two modes of drug release profile can be accomplished. Also, we carried out in vitro experiments and clarified the significantly increased anticancer activity according to the temperature difference. |
| 저자 |
노윤호1, 문주연1, 홍은지2, 김현웅1, 심민석1, 봉기완1
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| 소속 |
1고려대, 2인천대 |
| 키워드 |
hydrogels; microparticles; drug delivery; flow lithography
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| E-Mail |
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