| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.326 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | A Monte Carlo Simulation for Recognition due to Pattern Matching between Protein-ike Heteropolymer and Designed Surface |
| 초록 | Biopolymers adsorb on cell and virus surfaces with great specificity. By recognition, the protein adsorbs strongly on the pattern-matched region, and not on other parts of the surface. Recently, computational studies have inquired as to whether there are any universal design strategies that nature employs in order to affect such recognition. In this study, several design strategies and their efficacy are explored. To model a protein sequence used for recognition, sequences are designed by sequence annealing method based on Kawasaki model. The adsorption of the model proteins onto the patterned surface is then simulated by using a dynamic Monte Carlo method according to Verdier-Stockmayer algorithm. From the simulation results, it is found that a sharp transition from weak to strong adsorption occurs when the sequence of protein and surface site distributions are related in a specific way. Varying the pattern of surface, various static and dynamic properties of the adsorption process of the proteins are measured and the results are discussed in conjunction with the thermodynamic and kinetic efficiency of the protein recognition. |
| 저자 | 이인호, 허준, 조원호 |
| 소속 | 서울대 |
| 키워드 | |
