| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
콜로이드계면화학_포스터 |
| 제목 |
Tuning the toughness of an Alginate microgel for cell-instructed Delivery |
| 초록 |
The encapsulation of live cells in calcium cross-linked alginate gel has been extensively studied. However, biological use of alginate gel has been limited by the low structural integrity of the gels for a long-term cell culture condition. Therefore, in this study, we demonstrated that the incorporation of sequential covalent cross-links in an ionically cross-linked alginate gel using synthetic and natural hybrid polymers. This strategy tuned the toughness of an encapsulated alginate micro-ball and further regulated the targeted cell delivery in terms of growth and differentiation of neuron cells encapsulated in the gels. The balls were opened by the force that the cells pull the gel fiber by the differentiation of the cells and the micro-balls can deliver the live neuron cells. Overall, the results of this study will be highly useful in designing encapsulation devices with tuned structural integrity for regulating various functions of live cells. |
| 저자 |
오승주, 김희진, 조성우, 한사라, 신성규, 정재현
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| 소속 |
숭실대 |
| 키워드 |
cell-instructed delivery; alginate microgel; work to fracture; elastic modulus; neuron cell
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| E-Mail |
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