| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
19권 2호 |
| 발표분야 |
고분자_포스터 |
| 제목 |
Photosensitizer-Loaded Gas-Generating Mineralized Nanoparticles for Theranostic Applications |
| 초록 |
Theranostic nanoparticles have been widely applied for the improvement of tumor treatment. Herein, we develop a gas-generating calcium carbonate (CaCO3) mineralized nanoparticle (CaCO3-MNPs) that can generate CO2 bubbles and trigger the release of photosensitizers (chlorin e6 (Ce6)) in response to tumoral acidic pH for ultrasound (US) imaging and simultaneous therapy of tumors. The CaCO3-MNPs generated strong echogenic signals at tumoral pH (6.4) due to CO2 bubble generation. In contrast, at pH 7.4, there was no noticeable US contrast signals. Besides, the CaCO3-MNPs effectively released Ce6 at pH 6.4, and expressed the effective photodynamic therapeutic activity for MCF-7 breast cancer cells. The Ce6-loaded CaCO3-MNPs can serve as a useful theranostic agent for imaging-guided photodynamic therapy. |
| 저자 |
이상천, 정서영, 이홍재, 김기덕, 민경현, 박동진
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| 소속 |
경희대 |
| 키워드 |
Theranostic; calcium carbonate; US contrast; Ce6; photodynamic therapy
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| E-Mail |
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