| 학회 |
한국공업화학회 |
| 학술대회 |
2014년 가을 (11/12 ~ 11/14, 엑스코(대구)) |
| 권호 |
18권 2호 |
| 발표분야 |
신진과학자포럼 |
| 제목 |
Large scale synthesis of self-assembled DNA structures for siRNA delivery applications |
| 초록 |
DNA nanotechnology has been employed in various drug delivery applications especially for the intracellular delivery of siRNAs. Self-assembled DNA nanostrcutures have distictintive advantages over conventional gene delivery carriers such as facile control of particle size and shape, good biocompatibility and biodegradability. Inspired by isothermal enzymatic process of rolling circle amplification of DNA strands, our group has developed a system to prepare more than 200 fold increase of DNA nanostructures using a single-stranded circular DNA template. These systems are able to deliver various siRNA conjugates in selective cancer cells and show markedly higher gene silencing effect with a dose dependent manner. |
| 저자 |
이혁진 |
| 소속 |
이화여자대 |
| 키워드 |
Self-assembly; DNA nanostructures; siRNA delivery
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| E-Mail |
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