| 초록 |
Nano-sized self-assemblies formed with amphiphilic block or graft copolymers have been extensively studied to use them in a variety of biological and industrial application including a drug delivery. In this study, a poly(2-hydroxyethyl aspartamide) (PHEA) grafted with retinoic acids, which could form self-assemblies in an aqueous solution, was successfully synthesized. Then, controlling the degree of substitution of retinoic acids induced the tailored size and structure of the self-assemblies by inter/intra molecular stacking of retinoic acids. Retinol is essential for healthy skin, but very unstable in heat, light and air, rendering it useless if overexposed. The retinal was stably encapsulated into a core of self-assembled nanoparticle with 10% of DS. This strategy to prepare the self-assemblies of amphiphilic polyaspartamide will serve to improve the efficiency of targeted delivery for a functional cosmetic with various biological modalities. |
