| 초록 |
Biocompatible with amphiphilic block or graft copolymers in particulate carrier systems have been extensively studied for pharmaceutical and cosmeceutical application. In this study, a poly(2-hydroxyethyl aspartamide) (PHEA) grafted with retinoic acid, which could form self-assemblies in an aqueous solution, was successfully synthesized. Then, controlling the DS of retinoic acids induced the tailored size and structure of the self-assemblies by inter/intra molecular stacking of retinoic acids. Retinol is essential for healthy skin, but very unstable in heat, light and air, rendering it useless if overexposed. The retinol was stably incorporated into a core of self-assembled nanoparticle with 10% of DS. This strategy to prepare the self-assemblies of amphiphilic polyaspartamide will serve to improve the efficiency of targeted delivery for a functional cosmetic with various biological modalities. |
