| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Elastin Fusion Proteins with Coiled-coil Domains for Stimuli-triggered Self-assembly |
| 초록 |
Stimuli-responsive self-assembly of protein-based biomaterials have been studied for various biomedical applications such as drug delivery, tissue engineering and regenerative medicine. In this study, we report molecular design, biosynthesis, purification and characterization of elastin fusion proteins with coiled-coil domains for stimuli-triggered self-assembly. We showed that the elastin-based polypeptide (EBP) middle block provided thermally-triggered aggregated domains above its lower critical solution temperature (LCST) while coiled-coil domains at both ends forming intra- or intermolecular physical cross-linking due to their amphipathic characteristics. The stimuli-triggered self-assembly of the elastin fusion proteins with coiled-coil domains would open a new avenue for physically cross-linked protein-based micelles and hydrogels. |
| 저자 |
임동우1, 강민정2, 이재상3, Aamna Basheer4
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| 소속 |
1Department of Bionanotechnology, 2Hanyang Univ., 3ERICA Campus, 4Department of Bionano Engineering |
| 키워드 |
Elastin; Coiled-coil; Stimuli-responsiveness; Physical cross-linking; Self-assembly
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| E-Mail |
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