| 초록 |
We herein propose a new transdermal nanocarrier system, which can take both inter- and intracellular pathways. For this, polymer-lipid hybrid micelles are fabricated by tailored co-assembly of amphiphilic poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) and bio lipid, mannosylerythritol lipid (MEL). Thanks to asymmetric alkyl chain configuration of MEL, the micelles fabricated in this study show structural flexibility and deformability, which can be confirmed by XRD, DSC, and NMR analyses. Those properties enable the micelles to pass through between intercellular lipids in the stratum corneum. Moreover, the conjugation of cell-penetrating peptide (CPP) to MEL induces interaction with the skin cell membrane so that micelles can also deliver drugs via intracellular pathway. From combined in vivo and in vitro skin penetration studies, finally, we show that the micelles remarkably improve transdermal delivery efficiency. |
