| 초록 |
This study introduces a new transdermal delivery system in which drug molecules encapsulated in polymeric micelles are delivered to dermal-epidermal junction (DEJ). For this, phase modulus-regulated polymeric micelles were fabricated via self-assembly of mixed amphiphilic triblock copolymers, poly (ethylene oxide)-b-poly (ε-caprolactone)-b-poly (ethylene oxide) and poly (ethylene oxide)-b-poly (dimethylsiloxane)-b-poly (ethylene oxide). The modulus of micelle phase could be controlled just depending on the composition of triblock copolymers, which was confirmed from XRD, DSC, and NMR analyses. The polymeric micelles with well-tuned phase modulus readily penetrated into the stratum corneum and reached to DEJ. Conjugation of cell-penetrating peptide enhanced transdermal delivery even more. Based on these results, we optimized transdermal delivery systems and conditions for DEJ targeting. |
