| 초록 |
Here, we present the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino-acid interactions. DNA-b-poly(amino acid) assemblies can undergo protease-induced fiber-to-sheet shape transformations, where the morphology change is dictated by the type of enzymes and amino acid sequences. Furthermore, we have demonstrated that unique Janus 2D DNA assemblies can be fabricated by the highly directional peptide self-assembly. The peptide-based self-assembly reported here provides a programmable approach to fabricate dynamic DNA assemblies with unusual low-dimensional structures. |
