| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.22 |
| 발표분야 | 의료용 주입형 하이드로젤 |
| 제목 | Novel thermosensitive injectable polymers for biomedical applications |
| 초록 | The interest for tissue engineering and drug delivery system has grown in importance over recent years with development of new injectable polymers. A large number of injectable polymer have been developed and they can be induced by several different mechanisms such as viscosity and some external stimuli. The thermosensitive approach can be more advantageous for particular applications as it does not require organic solvents, copolymerization agents, or an externally applied trigger for gelation. Additionally, injectable polymer with biofunctionality has been attractive, which can effectively supplement physiological activities to materials through hybridization with bioactive agents. In our laboratory, novel injectable systems using thermosensitive polymers have been studied and they can be divided into three categories, which possess thermosensitivty; Chitosan-g-NIPAAm, Chitosan-Pluronic, Tetronic-PLA(PCL)-heparin. The common characteristics of these copolymers are to show LCST in their aqueous solutions and can be solidified by phase transition around body temperature. They showed good cell compatibility and furthermore, in chitosan-g-NIPAAm, had a good potential for chondrogenesis from mesenchymal stem cells (MSCs) in vivo. Tetronic-PLA(PCL)-heparin were prepared as an intelligent gel matrix for medical multipurpose. This copolymer can control the cell functions by specific interactions with various growth factors as well as hemocompatibility due to the effect of bound heparin. Therefore, In situ gel forming injectable system using these thermosensitive polymers can be utilized with great potentials for implants, tissue engineering and drug delivery system. Fig. 1. Bladder injection of the MSCs encapsulated chitosan-g-NIPAAm Fig. 2. Sol-gel transition of Tetronic-PLA-heparin copolymer Acknowledgements This work was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (02-PJ3-PG6-EV11-0002) References 1. JW Lee, MC Jung, HD Park, KD Park, GH Ryu, J Biomat Sci Polym Ed, 15:8, 1065 (2004) 2. KS Jee, HD Park, KD Park, YH Kim, JW Shin, Biomacromolecules, 5, 1877 (2004) |
| 저자 | 박기동1, 이준우2, 배진우1, 고동현1 |
| 소속 | 1아주대, 2한국과학기술정보(연) |
| 키워드 | thermosensitive hydrogel; injectable; chitosan; heparin; |
