| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Targeted cellular delivery of robust enzyme nanoparticles for treating drug-induced hepatotoxicity |
| 초록 |
We synthesized hydrophilic natural polymer with inorganic calcium phosphate for the facile preparation of a SOD-containing bio-hybrid nanoparticle system. The polymer has multiple functions such as liver-targeting property, endosomal escape function, and desirable stability in the blood stream. d-HA/SOD was synthesized by reacting catechol moieties of d-HA with surface amines of SOD. CaP/d-HA/SOD was successfully prepared and stabilized by preventing excessive growth of CaP and inter-particular aggregation. Cellular uptake of CaP/d-HA/SOD was significantly increased by CD44-mediated endocytosis and dissociation of calcium and phosphate ions. The targeted nanoparticles not only improved radical scavenging activity but also reduced oxidative stress-mediated apoptosis. Systemically injected CaP/d-HA/SOD showed therapeutic effects in preventing APAP-induced hepatic toxicity and injury in animals. |
| 저자 |
정재백, 정지훈, 이민상, 김다훤
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| 소속 |
성균관대 |
| 키워드 |
Protein delivery; Systemic delivery; Targeted delivery; Calcium phosphate ions
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| E-Mail |
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