| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Multi-layer coated nanoparticles for delivery of oligonucleotides into multidrug-resistant bacteria |
| 초록 |
Bacterial infections have been a major cause of mortality worldwide. The overuse of broad-spectrum antibiotics has given rise to the emergence and spread of antibacterial resistance, which has become a serious threat to public health. Nanoparticle-based gene delivery systems that inhibit the expression of target genes provide an alternative treatment option in combating multidrug-resistant bacterial infections with high selectivity. Multi-layer coated gold nanoparticles (AuNPs) were prepared by sequential modification of AuNPs with polyethyleneimine (PEI) and oligonucleotides. The multi-layer coated AuNPs were efficiently taken up into MRSA and resulted in inhibition of bacterial growth. This study presents a novel application of gene delivery systems in the treatment of multidrug-resistant bacterial infections that can overcome limitations of conventional antibiotics. |
| 저자 |
Marcel Janis Beha |
| 소속 |
카이스트 |
| 키워드 |
Nanoparticle-based drug delivery; gene silencing; multidrug-resistant bacteria
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| E-Mail |
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