| 학회 |
한국재료학회 |
| 학술대회 |
2014년 봄 (05/15 ~ 05/16, 창원컨벤션센터) |
| 권호 |
20권 1호 |
| 발표분야 |
D. 바이오 재료(Biomaterials) |
| 제목 |
Bone regenerating properties of surface modified Silicon-doped BCP micro-channeled granular bone filler in rabbit femoral head defect |
| 초록 |
Silicate-doped biphasic calcium phosphate (SiBCP) granular bone fillers of 1mm in diameter and height with seven 100-μm micro-channels were surface modified with collagen and loaded with BMP-2 (SM-SiBCP). SiBCP and SM-SiBCP granules were implanted on 5mm size defects on rabbit femoral heads and compared the bone regeneration against a control after 1, 4 and 8 weeks. Significant bone formation is already observed in the 1 week samples implanted with the granules according to the reconstructed micro-CT images although some inflammation occurred with the SM-SiBCP from the histological analysis. After 4 weeks, bone formation reached up to 44.72% for SiBCP and 46.31% for SM-SiBCP with half of the total volume being mature bone. After 8 weeks of implantation, bone formation from SM-SiBCP became significantly highest at 62.76%, SiBCP at 53.62% and control with 53.90% although completely composed of soft tissue. These results showed that the surface modified micro-channeled granules showed potential for bone tissue regeneration. |
| 저자 |
Nathaniel T. Carpena1, Dong-Woo Jang2, Swapan Kumar Sarkar3, Byong-Taek Lee1
|
| 소속 |
1InoBone, 2Cheonan, 3South Korea |
| 키워드 |
Bone regeneration; Calcium phosphate; BMP; Silicate; collagen; in vivo test
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| E-Mail |
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