| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Photo- and pH-responsive Amphiphilic Polycarbonate Block Copolymer Pro-drug Micelles for Controlled Release of Doxorubicin |
| 초록 |
In this, study we have synthesized two novel Amphiphilic polycarbonate diblock copolymers with pendant alkyne functionalised o-nitrobenzyl ester groups synthesized via organo catalytic ring-opening polymerization (ROP) using monomethylether poly(ethylene glycol) (mPEG) as the macroinitiator. The polymers functionalised with alkyne were transformed into aldehyde functionalities by azide-alkyne click reaction. The anti cancer drug Doxorubicin (DOX) was covalently conjugated to the polymers via pH sensitive schiff’s base linkage. The Amphiphilic block copolymers self-assemble in pH buffered saline PBS (pH 7.4) with hydrodynamic size of about 20 nm spherical micelles. The morphology and size of the micelles were studied using transmission electron microscope (TEM) and dynamic light scattering (DLS). Photo cleavage of o-nitrobenzyl ester group was studied by gel permeation and NMR spectroscopy. pH and photo induced stimuli-responsive DOX release was studied. |
| 저자 |
칼바 나겐드라, 김일
|
| 소속 |
부산대 |
| 키워드 |
ring-opening polymerization; drug delivery; block copolymers
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| E-Mail |
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