| 초록 |
Mechanobiology is a field of science at the interface of biology and engineering and focuses on the way that physical forces and changes in cell or tissues mechanics contribute to development, physiology, and pathological condition. A number of tubular organs exist in our body, e.g. blood and lymphatic vessels, airways of lungs, and urethra, inside which fluids flow and exert mechanical forces, e.g. hydrostatic pressure, circumferential stress, and shear stress. Characteristics of the mechanical force vary upon geometrical and mechanical properties of luminal walls, which may also be varied during development or pathogenesis. Here we present the unique method to develop the soft tubular microfluidic device that recapitulates geometrical and mechanical properties, and thus the forces exerted by fluids, of vasculatures and their pathological condition. For future studies, we aim to explore the effects of the forces exerted by the blood on ECs attached on the hydrogel channel. |
