| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
휴먼인터페이스 의료용 고분자재료 (의료용 고분자 부문위원회) |
| 제목 |
Efficiency of chitosan nanoparticle for therapeutic agent delivery |
| 초록 |
The aim of this study is to confirm the effect of chitosan with different molecular weight and fatty acid (FA) with hydrophobic chain length. FA was modified to chitosan by EDC coupling agent. FA-modified chitosan nanoparticle (ChNP) was self-assembled by hydrophobic interaction. It was known that Curcumin has therapeutic effect against angiogenesis, inflammatory, and cancers. Despite of these advantages, it has a few problems such as cytotoxicity, low solubility, and poor absorption in human body. Therefore, ChNPs were prepared to overcome these problems. The characterization of ChNPs were investigated by FT-IR, 1H-NMR, DLS, and HPLC. Cell viability and anticancer activity were evaluated by MTT assay. This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology(2011-0012039) |
| 저자 |
장재영, 김태훈, 남정표, 박성철, 나재운, 장미경
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| 소속 |
순천대 |
| 키워드 |
Therapeutic agent; chitosan; fatty acid; anticancer activity.
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| E-Mail |
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