| 초록 |
The new paradigm establishes polymeric nanoparticle-based theragnosis as a new method for molecular imaging, early diagnosis, and drug delivery system. With the help of polymer chemistry, we propose two different novel strategies using polymeric nanoparticles for the development of smart probes and new drug carriers for the treatment and imaging various diseases. First, we propose a new drug delivery system for cancer theragnosis based on the nanoparticle-based technology. Our new optical imagining system allowed real-time and non-invasive evaluation of nanoparticles’ biodistribtuin in vivo and revealed that nanoparticles were only localized in tumor site. Second, self assembled and near-infrared fluorescence auto-quenched nanoparticular probes have been designed to visualize target molecules, such as proteases and protein kinases, in cellular levels. These nanoparticles should prove useful in cell-based high-throughput screens for chemicals that trigger apoptosis or protein kinases. |
