| 초록 |
Proteins are important biologic therapeutics used for the treatment of various diseases. However, owing to low bioavailability and poor skin permeability, transdermal protein delivery poses a significant challenge. Here, we present a new approach for transdermal protein delivery using bullet-shaped microneedle(MN) arrays with swellable tips. This design provided an optimal geometry for mechanical interlocking, thereby achieving significant tissue adhesion. Additionally, prolonged release of loaded proteins by passive diffusion was obtained. By harnessing reversible swelling/deswelling property, insulin was loaded in the swellable tips using a mild procedure. The insulin-loaded MN patch released 60% of insulin for 12h and ~ 70% of the released insulin appeared to have preserved structural integrity. This self-adherent transdermal MN platform can be applied to diverse protein drugs requiring sustained release kinetics. |
