화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터)
권호 44권 2호
발표분야 기능성 고분자
제목 Doxorubicin Delivery via Well-Defined Poly(N-vinylprrolidone)-b-Poly(vinylpyridine) pH-Sensitive Block Copolymer
초록 To avoid side effects of anti-cancer drugs, using drug delivery system is important to protect mormal organs and save drug dosage. Cancer cell has abnormally active metabolism, so it creates much amount of lactic acid, lower pH than normal cell. Using this factor, if pH-sensitive materials are included in drug delivery system, it would release anti0cancer drug only at tumor cells. Though some pH-sensitive drug delivery studies are done, they still have own drawbacks to be used in human body. Herein we study new and well-defined type of pH-sensitive block copolymer. Poly-vinylpyrrolidone is biocompatible and has better water solubility than poly-ethylene glycol. Vinylpyridine is biocompatible if polymerized, pH-sensitive, and has hydrogen bonding ability against doxorubicin, one of the anti-cancer drugs including hydoxyl groups. This simple drug loading principle will lead multi-drug loading, like paclitaxel, whose better performance were reported if combined with doxorubicin.
저자 임준섭, Avnish Kumar Mishra, 김진곤
소속 포항공과대
키워드 Block copolymer; drug-delivery
E-Mail jkkim@postech.ac.kr