| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.248 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Evaluation of Small Intestinal Submucosa (SIS) Sheet for Wound Healing |
| 초록 | Recently, wound dressings are used as a temporary wound covering to promote wound healing and prevent wound contamination. Porcinal small intestinal submucosa (SIS) as a new material mainly composed of collagen, glycosaminoglycan, and various growth factors, has been widely used as organ reconstructions and wound dressing without immuno-rejection responses. SIS sheets were treated with different concentrations (0-100 mM) of 1-ethylene-3-(3-dimethylaminopropyl) carboiimide hydrocholoride (EDC) for 24 hrs. And we prepared SIS sheets by spreading and freeze-drying. The prepared SIS sheets were evaluated their characteristics such as water uptake ability, tensile strength, elongation, surface morphology and biocompatibility of NIH/3T3. The biocompatibility of NIH/3T3 was found to be acceptable at cell density of 2×104 cells/cm2. From this study, SIS is regarded as an appropriate biodegradable material able to dress the wound like a burn in substitution of the traditional artificial composite materials the expected to be used as the biological dressings. Acknowledgement : This work was supported by Korea Ministry of Commerce, Industry and Energy (N11-A08-1402-05-1-3). |
| 저자 | 김선화1, 최진산2, 신혜원1, 강길선1, 이상진2, 김문석2, 조선행2, 이해방2 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | SIS; wound healing |
