| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
고분자가공/복합재료 |
| 제목 |
The Effect of Particle Size and Shape of Micron-sized Silk Fibroin as a Filler on Alginate Hydrogels |
| 초록 |
Alginate (Alg) is a polysaccharide which exists widely in the cell walls of brown algae. Multivalent cations can be incorporated into the chain of Alg, which forms ionic crosslinking. The high biodegradability and non-toxic property of Alg made it possible to be applied to tissue engineering. However, its mechanical properties are not enough to be used for cartilage or bone scaffolds. Silk fibroin (SF) from the silkworm has high strength and toughness, so we chose it as a filler on Alg hydrogels. To be incorporated into the hydrogels, SF is alkaline-hydrolyzed to micron-size. We adjusted the hydrolysis conditions and sorted the fabricated micron-sized SF (MSF) into two groups by aspect ratio and dimensions: SF microfibrils and SF microparticles. In this study, the effect of size and shape of MSF on hydrogels is evaluated. Optical microscopy and XRD are conducted on MSF for structural analysis, and UTM tests are performed to confirm the reinforcement effect of MSF on Alg hydrogels. |
| 저자 |
김지환, 김정수, 이현지, 전경화, 양세준, 이기훈
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| 소속 |
서울대 |
| 키워드 |
silk fibroin; micron-size; alginate; hydrogel
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| E-Mail |
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