| 초록 |
Tissue adhesions are associated with numerous postoperative complications, including patient's pain, functional obstruction, and difficult reoperative surgery. To solve these problems, various synthetic and natural polymer films, nonwoven fabrics, or gels as tissue adhesion barriers have been investigated. Among them, gel-type materials have particularly been interested because they have a ideal property (injectable or coatable) for use in laparoscoic surgery. Recently, several investigators have evaluated the use of aqueous Pluronic F127 gel as a tissue adhesion barrier because it is biocompatible and bioresorbable and it has an unique lower critical solution temperature (LCST) property. But its LCST is too low than room temperature, which is practically inconvenient to use for surgery. In this study, we prepared LCST-controllable Pluronic F127/F68 mixture gels including mildly crosslinked alginate as a injectable or coatable tissue adhesion barrier. The LCST of the Pluronic gels could be controlled by adjusting F127 and F68 ratio. The mildly crosslinked alginate acts as a thickening agent of the gels. The prepared gels were evaluated by the investigation of physical properties (injectability, LCST, stability in water, etc.) and postsurgical tissue adhesion reducing property through animal study using rat model.
|
