| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
DNA-Coated Polymer Nanoparticles from Block Copolymer Micelles |
| 초록 |
DNA-coated particles are promising building blocks for self-assembly which can realize many unconventional super-structures due to its orthogonal and addressable binding characteristics. We demonstrate a strategy for synthesis of DNA-coated polymeric nanoparticles using block copolymer micelles as a template. Diblock copolymers, polystyrene-b-poly(ethylene oxide), having azide group are self-assembled into spherical micelles, of which cores are then swollen with styrene monomer and polymerized resulting PEO-N3 brushed polystyrene nanoparticles. Their diameter is controlled in the range of 65~150 nm by changing the amount of monomer absorbed to the micelles. DNA strands are conjugated with particle surfaces through copper-free, click chemistry. Finally, using the DNA-coated polymer nanoparticles we made various cluster structure through temperature control. We expect that our strategy can be used for designing various kinds of DNA-coated polymeric nanoparticles |
| 저자 |
이새롬1, 조인성1, 오준석1, 심태섭2, David J. Pine3, 이기라1
|
| 소속 |
1성균관대, 2아주대, 3뉴욕대 |
| 키워드 |
DNA; self-assembly; nanolparticles; micelle; block copolymer
|
| E-Mail |
|
