| 초록 |
Obesity is related with the risk to induce several severe diseases, such as metabolic disorder, cancer and heart diseases. As excessive fat is accumulated in white adipose tissues, a therapy to target the abnormal fatty region is necessary. In this work, we developed hyaluronic acid (HA) conjugated hollow gold nanosphere (HAuNS) with adipocyte targeting peptide to photothermally ablate adipocyte tissues. The characteristics of HA-HAuNS/peptide complex were analyzed by DLS, UV-Vis absorption spectra and TEM. Silver enhancement staining of the abdominal skin tissue after topical treatment of HA-HAuNS/peptide complex could visualize the distribution of the complex within the skin tissue. Furthermore, we could confirm the in vivo anti-obesity effect of HA-HAuNS/peptide complex with laser irradiation by photoacoustic imaging. Taken together, we confirmed target specific delivery of the complex to adipose tissue and successful photothermal lipolysis. |
