| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Engineered self-expander hydrogel for sustained release of drug molecules |
| 초록 |
We present here a preparation of copolymer hydrogel composed of methyl-methacrylate and N-vinyl-2-pyrrolidone and in vitro release of anti-cancer drug doxorubicin from the self-expanded hydrogel in a physiological condition. The degree of expansion of self-expander copolymer was measured in various solutions and compared with commercially available expanders. We investigated the drug release profile of self-expander hydrogel loaded with doxorubicin before crosslinking. Anti-tumor effects of released drug molecules were evaluated by co-culturing self-expander copolymer with NIH3T3 cells or HUVEC control. Drug contained self-expander hydrogel may have a potential in biomedical applications, for example, implantation at the tissue area that requires physical support as well as anti-inflammatory drug release. |
| 저자 |
김지은1, 김동명2, 강호창2, 최종훈1
|
| 소속 |
1한양대, 2Probiomimetic Research Center |
| 키워드 |
self-expander; hydrogel; drug release; MMA; VP
|
| E-Mail |
|
