| 초록 |
Polymer nanoparticles have been developed as smart nanocarriers for cancer therapy. For successful cancer therapy, they need to satisfy several requirements, such as robustness in systemic blood circulation and facilitated drug release within the target tissue. To meet these requirements, various shell or core cross-linking techniques have been developed. Recent reports suggested that a coordination bond between Fe3+ and catechol ligands has a pH-responsive reversible association/dissociation property. As pH decreases from 7.4 to 5.0, the complex of catechol-Fe3+ changes from bis-complex to mono-complex. Herein, we develop pH-responsive polymer nanoparticles composed of a PEG shell and a Poly(L-DOPA) core, in which the Poly(L-DOPA) core was cross-linked by Fe3+. This nanoparticle may effectively hold the drug at physiological pH and trigger the accelerated drug release in the acidic endosome of target disease cells. |
