| 초록 |
The plants derived polymers have been used for biomedical applications because of their numerous effects. Due to their high mechanical strength, which is desirable for use in a drug delivery system (DDS) to maintain the high durability without any drug leakage issue in body. In this study, we have prepared high durable DDS carriers using plant-extracted polymers, tannic acid (TA) and lignin. By using Layer-by-layer assembly (LbL), we have fabricated TA and lignin multilayer microcarriers. The TA and lignin carriers were stable at physiological condition for 7 days, started to degrade when depolymerized enzyme treated. We also controlled film degradation and drug release kinetics enzymatically and pH-dependent. The TA and lignin carriers did not show cytotoxicity and have anticancer effect depending on the drug release manners. We have first developed a smart drug delivery carrier using plant cell extracts that can be controlled via enzymatic effects, which is useful as DDS platform. |
