| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
pH-Controlled Bubble-Generating Mineralized Nanoparticles for Ultrasound Imaging and Photodynamic Therapy. |
| 초록 |
In recent years, theranostic nanoparticles, which integrate imaging and therapeutic functionalities, have played a central role in the improvement of tumor treatment. Herein, we develop a bubble-generating calcium carbonate (CaCO3) mineralized nanoparticle (CaCO3-MNPs) that can generate CO2 bubbles and trigger the release of photosensitizers in response to tumoral acidic pH for ultrasound (US) imaging and simultaneous therapy of tumors. In vitro experiments showed that the CaCO3-MNPs generated strong echogenic signals at tumoral pH (6.4) due to CO2 bubble generation, whereas, at pH 7.4, there was no noticeable US contrast signals. In addition, the CaCO3-MNPs effectively released the photosensitizer at pH 6.4, and expressed the effective photodynamic therapeutic activity for MCF-7 breast cancer cells. The photosensitizer-loaded CaCO3-MNPs can serve as a useful theranostic agent for imaging-guided photodynamic therapy. |
| 저자 |
박동진, 민경현, 이홍재, 이재원, 남혜영, 정서영, 이상천
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| 소속 |
경희대 |
| 키워드 |
Theranostics; Ultrasound Imaging; Photodynamic Therapy; Mineralization; pH-Controlled Nanoparticle
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| E-Mail |
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