| 초록 |
Various surface treatment approaches have been introduced to enhance osteogenic differentiation on dental implants. In particular, the surface immobilization of nanocontainers that can control the release of bioactive molecules has emerged as a promising technique. Herein, we report on the surface functionalization of titanium with adhesive nanoparticles (catechol-functionalized polyaspartate-b-polyphenylalanine micelles) for controlled incorporation and the release of BMP-2. BMP-2 was loaded onto the anionic polymer nanoparticles immobilized on the Ti surface by the electrostatic interaction. To determine the osteogenetic effect, cellular attachment and proliferation, alkaline phosphatase (ALP) activity and calcium mineral deposition were assessed. The Ti-adhesive nanoparticle may find many applications as a surface releasing system for medical devices including stents and dental implants. |
