| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation and Characteristics of Intelligent Pluronic Hydrogels for Tissue Engineering |
| 초록 | Pluronics are nontoxic poly(ethylene oxide)-(polypropylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers including F127 which form thermoreversible gels at high concentrations. These gels have received increasing attention over many years as drug delivery systems, biomaterials, and hydrogels for tissue engineering.1,2 In this study, F127 was chemically modified to yield intelligent hydrogel for tissue regeneration. Temperature-sensitive, biodegradable, and cell adhesive triblock copolymer, META-F127-G-RGD, was synthesized by subsequent grafting of functional 4-methacryloxyethyl trimellitic anhydride (META), biodegradable glycolide (G), and then Arg-Gly-Asp (RGD) peptide ligand to F127.3 The chemical structures of the META-F127-G-RGD block copolymers were analyzed by FTIR, GPC, and 1H and 13C NMR. Sol-gel transition and particle size of the resulting META-F127-G-RGD copolymers were characterized by tube tilting method and light scattering. The interaction between the synthesized copolymers and chondrocytes was evaluated to improve the adhesion and proliferation of the cells in the hydrogel state. The resulting META-F127-G5-RGD showed very similar thermosensitive behaviors to F127, META-F127, and META-F127-RGD. The micelle size of the copolymers increased as the following order : F127 < META-F127 < META-F127-RGD < META-F127-G-RGD, whereas the critical micelle temperature (CMT) demonstrated the reverse trends. These intelligent Pluronic hydrogels that display thermosensitive, cell adhesive, and biodegradable characteristics are expected to be useful as a functional scaffold for tissue engineering. Fig. 1. Thermosensitive sol-gel behaviors of intelligent F127 derivatives. References 1. N. K. Pandit and J. Kisaka, Int. J. Pharm., 145, 129-136 (1996). 2. P. Holmqvist and A. Brodin, Int. J. Pharm., 194, 103-116 (2000). 2. U. Hersel, C. Dahmen, and H. Kessler, Biomaterials, 24, 4385-4415 (2003). |
| 저자 | 차승환1, 김종만2, 안광덕1, 한동근1 |
| 소속 | 1한국과학기술(연), 2한양대 |
| 키워드 | F127; RGD; Thermosensitive; Hydrogel |
