| 초록 |
A growing number of studies show that extracellular vesicles (EVs) may function as reliable surrogates of parental cells. With their abundance and structural stability, these vesicles can better reflect overall tumor burden, overcoming limitations of tumor heterogeneity and sampling bias. Rapid and accurate analysis of EVs is, however, hampered by practical challenges: 1) lengthy isolation procedures resulting low yield and poor purity, 2) lack of ultrasensitive bioassays and disease-specific biomarkers. Standardized bioassays, optimized for these nano-sized vesicles, have yet to be developed to fully evaluate EVs’ clinical potential. In this presentation, current efforts to develop advanced sensing systems for high-throughput analysis of EVs will be discussed. In particular, the clinical reliability of a nano-plasmonic sensor-based bioassay facilitating diagnosis of pancreatic malignancy and new approaches to develop plastic-based devices for point-of-care testing will be introduced. |
