| 학회 |
한국재료학회 |
| 학술대회 |
2012년 가을 (11/07 ~ 11/09, 라카이샌드파인 리조트) |
| 권호 |
18권 2호 |
| 발표분야 |
D. 바이오재료(Biomaterials) |
| 제목 |
Biocompatibility evaluation and anti-adhesive effects of biodegradable PVA/Gelatin membranes |
| 초록 |
A continuous problem for patients in abdominal surgery is the peritoneal adhesion that follows the operations as complication. As a prevention method, the blended Polyvinylalcohol (PVA)/Gelatin (Gel) was fabricated by casting method can serve as barrier to prevent the peritoneal adhesion. Characterization and material properties of various ratios of PVA and gelatin (10/90, 30/70 and 50/50) were evaluated based on Scanning Electron Microscope (SEM) observation, contact angle measurement, FT-IR spectrum and biodegradation rate. Cytocompatibility study of PVA/Gel membranes were examined by in vitro experiments for instance, observation of L-929 mouse fibroblast cells proliferation and live/dead cell staining were done using confocal microscopy and the MTT assay. For in vivo evaluation of tissue anti-adhesion, PVA/Gel membranes and commercial products (Surgiwrap®) were implanted to the artificial defect that created between cecum and peritoneal wall in abdominal rats for 1 week and 2 weeks, and compared their tissue adhesion extents with non-implanted PVA/Gel membrane. |
| 저자 |
So-Ra Son1, Swapan Kumar Sakar2, Sang-Ho Bae3, Young-Ki Min1, Byong-Taek Lee2
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| 소속 |
1Department of Biomedical Engineering and Materials, 2College of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
PVA; Gelatin; In vitro; In vivo; Anti-adhesion agent
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| E-Mail |
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