| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Lysine dendrimer modified chitosan for gene delivery |
| 초록 |
As a non-viral vector for gene delivery, chitosan is a low-gene-expression carrier despite its outstanding biocompatiblity and non cytotoxicity. For that reason, lysine dendrimer was modified to chitosan. Lysine is as an essential amino acid for humans and it has amino group (NH3+) and carboxyl (C=OOH) group. Therefore It is easy to manufacture as dendrimer and improve transfection efficiency. The chitosan-K dendrimer was complexed with pDNA and characterized by 1H-NMR, FT-IR and DLS analysis. In addition, binding ability and gene delivery efficiency were evaluated by gel electrophoresis and transfection assay. This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology(NRF-2011-0012039) |
| 저자 |
김준호, 박순정, 정경원, 남정표, 최창용, 박성철, 나재운, 장미경
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| 소속 |
순천대 |
| 키워드 |
gene carrier; GDS; Lysine; pDNA; polymer
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| E-Mail |
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