| 초록 |
Photodynamic therapy (PDT) utilizes reactive oxygen species (1O2) generated from photosensitizer after Near-Infrared (NIR) irradiation. PDT has been known as an effective therapeutic option owing to their minimal invasiveness as well as high selectivity by localized application of irradiation directly onto a disease site. Moreover, recent studies highlight that PDT-mediated immunogenic cell death (ICD) may also contributes to the therapeutic efficacy by utilizing body’s own immune system. However, most of PDT often suffers from unwanted side effects with unfavorable biodistribution and poor bioavailability of applied photosensitizers. Therefore, by utilizing enhanced permeation and retention (EPR) effect, nanoparticle-based PDT can improve cellular uptake, biodistribution and bioavailability. Recent studies on nanoparticle-based photodynamic imaging and therapy in our lab will be introduced and discussed in this talk. |
