| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | ROS producible hMSC complex for Tumor immunotherapy |
| 초록 | Last several years, Photodynamic therapy (PDT) has been verified their capability to trigger the immune system for killing cancer cells, since it is able to produce reactive oxygen species (ROS). Furthermore, to enhance the therapeutic efficacy of PDT, nanotechnology-based immunotherapy has been studied with PDT. However, there are several problems such as toxicity and their short half-life still remained. To resolve the limitations, we developed the immunotherapy with human mesenchymal stem cell (hMSC) complex which is composed of photosensitizers (PS) and polymers (hMPS). This complex can migrate to the lesion site, produce reactive oxygen species (ROS) and secretes cytokines without side effects of immune system. In vivo, we observed hMPS can recruit the immune cells since it secreted pro-inflammatory cytokines. Also, hMPS prohibited the tumor growth in the mouse model. Consequently, hMPS showed their potentials to be the platform for cancer immunotherapy. |
| 저자 | 진민영, 김경섭, 이주영, 한지은, 황희숙, 이종환, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | Human mesenchymal stem cell; cytokines; ROS; immunotherapy |
