| 초록 |
Polymeric compounds have been widely used as 3D scaffold preparation due to their excellent biocompatibility, biodegradability, processability and economic feasibility, and, in particular, PLGA has been most widely used for this purpose. However, acidification of adjacent tissues due to acidication by degradation byproduct of PLGA still remains as an unresolved problem. In this investigation, feasility of physical modification was attempted to improve the biocompatibility of PLGA scaffold. Physical and chemical properties such as porosity, biocompatibility, degradability, and chemical composition of the scaffold were evaluated using various analytical methods including SEM, FTIR, and EDX. Effects of PLGA scaffold modification on the biocompatibility of the scaffold, such as reduction of acidification, proliferation and differentiation of osteoblst due to degradation byproducts were evaluated using pH measurement, CCK-8 assay, and ALP assay. |
