| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | Highly efficient gene delivery system using tumor environment responsive materials |
| 초록 | Gene delivery has enormous potential as antitumoral therapy. In order to achieve efficient cargo delivery, nanotechnology have introduced diverse particles. But gene delivery effect is limited due to a lot of biological barriers. To overcome barriers, photochemical internalization (PCI) has recently emerged. The exact mechanism of PCI is based on destruction of extracellular or intracellular membranes by reactive oxygen species (ROS) upon laser irradiation. However, ROS mediated degradation of cargo genes have shown a limitation because genes could be altered due to photo-oxidation reaction. In this work, we established a stable photo/pH-responsive system using pH-responsive polymeric photosensitizer as a shielding material. This system is composed of cationic polymer and photosensitizer-conjugated pH-sensitive material to protect the genes from ROS during PCI-mediated gene transfection. In summary, our delivery system provided a superior tumor penetration and transfection efficacy. |
| 저자 | 김다혜, 박신정, 박우람, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | gene delivery; photochemical internalization; reactive oxygen species; pH-sensitive; nanotechnology |
