| 초록 |
Polymersomes have been investigated as robust nanocarriers that accommodate water-soluble guest molecules within the inner compartment surrounded by the block copolymer bilayers. Achieving high membrane transportability of small molecules without sacrificing the physical stability of the polymersome should be highly desirable. Thanks to the low glass transition temperature of the siloxane-based polymer block, these block copolymers self-assembled into cylindrical micelles and polymersomes in water without using organic solvents. All self-assembled structures were covalently stabilized by cross-linking between vinyl groups in the presence of photo-radical initiators in water. The cross-linked polymersomes retained structural integrity under harsh conditions like extreme sheer force and organic solvents. After repeated extrusions of the cross-linked polymersomes through the membrane, the polymersomes maintained the diameter and retained the cargo molecules within the inner compartment. |
