| 초록 |
Poly(lactide-co-glycolide) (PLGA) is a biocompatible and biodegradable polymer, and gold nanoparticles (GNPs) have also been used as biomaterials and have been found to have a positive effect on bone formation. In this study, we synthesized thiol end-capped PLGA (PLGA-SH) and used it for binding GNPs. This PLGA was processed into a sheet form via electrospinning. GNPs with an approximate size of 30 nm were attachedonto the PLGA-SH sheet surfaces (PLGA-GNPs). Characterization results show that the GNPs are well attached on the PLGA-SH sheet and it is possibleto control the GNPs load. Additionally, they were found to enhance osteogenic differentiation of human adipose derived stem cells. From these results, we have determined that the PLGA-GNP fibers can be useful as materials for boneregeneration and can also potentially serve as drug carriers. |
