| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Improvement of Gene Silencing and Development of siRNA Delivery by Dendritic Gold Nanoparticle |
| 초록 |
Small interfering RNA (siRNA) delivery system has been a therapeutic strategy in RNA interference (RNAi) by sequence-specifically silencing target gene. However, a rigid double-stranded structure of siRNA limits the formation of tight complex with conventional cationic carriers. Therefore, stabilization of siRNA/carrier complexes is a prerequisite for an efficient siRNA delivery. In this study, we synthesized dendritic gold nanoparticles (Au@MCs) by using polymeric micelles. Ionic interaction and physical interaction with Au@MCs stabilized the encapsulation of siRNA. As a result, the siRNA/Au@MCs contributed to serum stability and improved gene silencing effect. |
| 저자 |
김다훤1, 임수연2, 정재백2, 김동민2, 조희주2, 정지훈2
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| 소속 |
1성균관대, 2성균관 대 |
| 키워드 |
small interfering RNA; gold nanoparticles; stabilizing polymeric micelles; gene silencing
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| E-Mail |
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