| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Polymeric transfection carrier mediated cellular oxidative stress can be reduced by antioxidative component |
| 초록 |
Potential toxicity of nanomaterials is important because nano-scale materials often have different properties to macro-scale materials. Various nanoparticles with diameter of a few hundred nanometers were reported for oxidative injury, inflammatory responses, cellular cytotoxicity or genotoxicity. A major pathway responsible for the adverse effects is thought to involve oxidative stress which is often caused as a result of excess intracellular reactive oxygen species. Polyethylenimines(PEI) are among the most extensively studied cationic polymers for non-viral gene delivery. However, like most of polycations used in non-viral transfection protocols, relatively high cytotoxicity of PEI is considered a major drawback. In addition, it was recently reported that PEI and its copolymer can induce oxidative stress responses in epithelial cells and macrophages. Therefore, we designed an antioxidative transfection system that performs the combined delivery of antioxidant and nucleic acid drug |
| 저자 |
김동민, 정재백, 임수연, 김다훤, 조희주, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
Nonviral gene delivery; Polyplex; Nano; Antioxidative transfection system; Oxidative stress
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| E-Mail |
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