| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Nanoparticle-based delivery of nucleic acids for targeting multidrug-resistant bacteria |
| 초록 |
The spread of bacterial infections due to the acquirement of antibiotic resistance has emerged as a serious and urgent public health problem and has been a major cause of mortality worldwide. Methicillin-resistant Staphylococcus aureus (MRSA) expresses various surface and secreted proteins that are responsible for its virulence and the resistance to antibiotics. Nanoparticle-based gene delivery systems that inhibit the gene expression could provide an alternative treatment option against bacterial infections caused by multiresistant bacteria. Layer-by-layer assembled gold nanoparticles (AuNPs) were modified with polyethyleneimine (PEI), nucleic acids and fluorescein to efficiently deliver an antisense oligonucleotide for the inhibition of the mecA gene in MRSA and a small interfering RNA designed against staphylocoagulase into MRSA S. aureus CCARM 3798. AuNP-µPEI-siRNA-µPEI-Fluorescein (10 nM) nanoparticles were efficiently taken |
| 저자 |
Marcel Janis Beha, 정현정
|
| 소속 |
카이스트 |
| 키워드 |
Nanoparticle-based drug delivery; gene silencing; multidrug-resistant bacteria
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| E-Mail |
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