| 초록 |
Insufficient interaction of implants to bone tissues and bacterial infections leads to the failure of orthopedic and dental implants. To enhance bone tissue responses toward implants, functionalization of implant surfaces with ceramics, biomolecules and peptides have been widely studied. In particular, to further enhance osteogenic differentiation and bone tissue regeneration, biosignalling molecules such as bone morphogenic protein-2 (BMP-2), platelet-derived growth factor (PDGF), and bisphosphonates are immobilized onto the surface of implants. Here, we presented the functionalization and immobilization of bioactive molecules (i.e. BMP-2, PDGF, or bisphosphonates) onto implant surfaces and studied osteoblast functions in vitro and in vivo. Bioactive molecules-delivering implants are promising for the enhanced osteointegration and implant longevity in orthopedics and dentistry. |
