| 초록 |
Hydrogels are crosslinked hydrophilic polymer networks, giving them physical characteristics similar to native tissues. Recently, various crosslinking methods have been employed for the preparation of in situ forming hydrogels, including chemical and physical crosslinking. The crosslinking condition must be non-toxic and allow suitable polymerization rate for operation setting prior to clinical use. In this study, we report biocompatible and biodegradable composite hydrogels derived from N-hexanoyl glycol chitosan (HGC) and acetylated hyaluronic acid (AcHA) upon mixing, without the addition of a chemical crosslinking agent. The gelation is attributed to thermos-sensitivity of HGC and ionic crosslinking reaction between carboxyl groups of AcHA and amine group of HGC. These composite hydrogels provide a potential opportunity to use for tissue engineering applications. This work was supported by Porject No. PJ009956. |
