| 초록 |
In biomedical applications, biocompatibility, especially blood compatibility, is an important issue because biomaterials implanted in human body must perform without disturbing biological system. When foreign material contacts with blood, thrombus is formed on the surface. Platelet adhesion is thought to induce a cascade reaction of coagulation factors, which results in thrombus formation. We synthesized biodegradable hydrophobic PU/ hydrophilic PEGDA IPN having micro-separated structure to overcome the problems caused in the long-term clinical use. PU was modified using biodegradable poly (e- caprolactone) diol and the hydroxyl group of PEG was substituted to crosslinkable acrylate group having double bond, which induce photo-polymerization. PU/PEGDA IPNs were synthesized by changing the molecular weight of PEGDA and crosslink density of PU to investigate the effect of crosslink density on morphology, bulk and surface hydrophilicity and mechanical properties. |
