| 초록 |
Stratum corneum (SC) lipids have intensively beenapplied as a component of nanovesicles for enhancing skin barrier function, butthe structure of nanovesicles composed of SC lipids is unstable due to highpacking parameter of ceramide. Herein, we propose an extremely stable SCmimetic-nanovesicle system in which 1-O-acylceramide (1OA) facilitates tightinteraction between the multi-layers of SC model lipid vesicle containingceramide NP, stearic acid, and cholesterol, thus showing an improved long-termstability. Regardless of presence of 1OA in the nanovesicles, they maintainedtheir size and multi-lamellar structure. However, the addition of 1OA in thenanovesicles affects the inter-spacing distance and ceramide crystallinity,attributed to the acyl chain conformation of 1OA. These findings indicate that1OA is important for stabilizing the structure of nanovesicles containing SClipids. |
