| 초록 |
For dental implants with osseogenetic potentials, various surface treatment approaches have been employed to induce sustained growth factor release. Herein, we report on the novel polymer nanoparticles (catechol-functionalized polyaspartate-b-polyphenylalanine micelles) for the immobilization onto Ti surfaces and controlled BMP-2 release. The nanoparticles were successfully immobilized onto Ti surfaces by a simple dipping process without the pre-treatment of Ti surfaces. BMP-2 was loaded onto the anionic polymer nanoparticles immobilized on the Ti surface by the electrostatic interaction. The sustain release of BMP-2 could be controlled by the adjusting the feed amount of BMP-2. To determine the osseogenetic effect, cellular attachment and proliferation, alkaline phosphatase (ALP) activity and calcium mineral deposition were assessed. The Ti-adhesive nanoparticle may find many utilities as a surface releasing system for medical devices including stents and dental implants. |
