| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Poly(ethyleneimine)-Gold Nanoparticles as Computed Tomography Contrast Enhancing Agents |
| 초록 |
This study is related to polymer-gold nanoparticles (AuNPs) which are nontoxic and capable of remaining in the bloodstream for a long time. We developed the methods for synthesis of poly(ethyleneimine) (PEI)-AuNPs as computed tomography CT contrast enhancing agents. Branched PEI-capped AuNPs are prepared in aqueous polymer solution, which is based on the roles of PEI as a reductant and a stabilizer. The characteristics of PEI-AuNPs were studied by X-ray diffractometry, scanning electron microscopy, transmission electron microscopy, and particle size analysis. The size of PEI-AuNPs had a significant dependence upon PEI contents with an average diameter of 40-100 nm. The PEI-AuNPs exhibited a well-dispersed property in water owing to exceptional stability against agglomeration with excellent hydrophilicity and biocompatiblity. The results obtained in this study confirmed the feasibility of the PEI-AuNPs as a biomaterial for CT contrast enhancing agent. |
| 저자 |
김은정1, 도미애2, 이현주1, 장용민2, 김한도1, 최진현2
|
| 소속 |
1Department of Advanced Materials Science and Engineering, 2Kyungpook National Univ. |
| 키워드 |
CT; PEI; AuNP
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| E-Mail |
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